human glioblastoma cell lines ln18 (ATCC)
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human glioblastoma cell lines ln18
Human Glioblastoma Cell Lines Ln18, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 801 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+glioblastoma+cell+line/LN-18/pm42865590-53-0-5
Average 96 stars, based on 801 article reviews
Human Glioblastoma Cell Lines Ln18, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 801 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+glioblastoma+cell+line/LN-18/pm42865590-53-0-5
Average 96 stars, based on 801 article reviews
human glioblastoma cell lines ln18 - by Bioz Stars,
2026-10
96/100 stars
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In Vitro:Article Title: Biogenic Cu-Fe bimetallic nanoparticles induce apoptosis and inhibit invasion in glioblastoma cells. Article Snippet: 1 Faculty of Science, Department of Molecular Biology and Genetics, Erzurum Technical University, Erzurum, Türkiye 2 Erzurum Technical University, High Technology Application and Research Center (YUTAM), Erzurum, Turkey Abstract Background This study demonstrates the wide-ranging therapeutic potential of copper-iron (Cu–Fe) bimetallic nanoparticles (BNPs), which were synthesized using an environmentally friendly method involving Corylus avellana leaf extract.. Methods and Results Following phytochemical profiling of the aqueous extract via LC-MS/MS, the Cu–Fe BNPs were characterized and confirmed to be stable nanostructures with an average size of 20–30 nm.. Biological evaluations revealed selective cytotoxicity against U87-MG glioblastoma cells, with IC50 values of 11.8 μg/mL and 325 μg/mL for U87-MG and HDF cells respectively, resulting in a selectivity index (SI) of 27.54. MTT Assay:Article Title: Biogenic Cu-Fe bimetallic nanoparticles induce apoptosis and inhibit invasion in glioblastoma cells. Article Snippet: 1 Faculty of Science, Department of Molecular Biology and Genetics, Erzurum Technical University, Erzurum, Türkiye 2 Erzurum Technical University, High Technology Application and Research Center (YUTAM), Erzurum, Turkey Abstract Background This study demonstrates the wide-ranging therapeutic potential of copper-iron (Cu–Fe) bimetallic nanoparticles (BNPs), which were synthesized using an environmentally friendly method involving Corylus avellana leaf extract.. Methods and Results Following phytochemical profiling of the aqueous extract via LC-MS/MS, the Cu–Fe BNPs were characterized and confirmed to be stable nanostructures with an average size of 20–30 nm.. Biological evaluations revealed selective cytotoxicity against U87-MG glioblastoma cells, with IC50 values of 11.8 μg/mL and 325 μg/mL for U87-MG and HDF cells respectively, resulting in a selectivity index (SI) of 27.54. Modification:Article Title: Iodinated contrast agents decrease the activity of multidrug resistance protein, cell migration, and induce cell death in different tumor cell lines and glioblastoma spheroids. Article Snippet: Iodinated contrast agents are a class of compounds widely used in diagnostic medicine to enhance images of tissues subjected to X-ray techniques.. Previous studies have shown that radiocontrast agents are capable of increasing the generation of reactive oxygen species (ROS) and inducing the activation of apoptosis in tumor cells, making these compounds an alternative for cancer treatment.. However, there is a lack of studies on their antitumor action in chemotherapy-resistant tumors. Article Title: Harnessing Argonaute 2 as an Innovative Delivery System for siRNA in Glioblastoma Treatment Article Snippet: RNA interference via small interfering RNA (siRNA) offers promising potential for treating glioblastoma (GB), the most common and aggressive primary brain tumor.. While local siRNA delivery could bypass the blood-brain barrier and achieve high drug concentrations, challenges remain in developing effective delivery systems that ensure siRNA stability, efficient cellular uptake, endolysosomal escape, and long-term brain availability.. The Argonaute-2 (Ago2) protein, a core component of the RNA interference machinery, naturally binds siRNA and protects it from degradation. Cell Culture:Article Title: Enhanced Radionuclide Therapy via the Conjugation of Pentadecanoic Acids With 225 Ac- and 177 Lu-Labeled RGD Peptides. Article Snippet: .. Cells from the human pancreatic cancer cell line BxPC- 3 (ECACC, UK Healthy Security Agency, UK) were cultured in RPMI 1640 supplemented with 10% fetal bovine serum (FBS), whereas those from the Article Title: Macrophages rescue cells from ferroptotic death. Article Snippet: .. Cell culture –The Luciferase:Article Title: Harnessing Argonaute 2 as an Innovative Delivery System for siRNA in Glioblastoma Treatment Article Snippet: RNA interference via small interfering RNA (siRNA) offers promising potential for treating glioblastoma (GB), the most common and aggressive primary brain tumor.. While local siRNA delivery could bypass the blood-brain barrier and achieve high drug concentrations, challenges remain in developing effective delivery systems that ensure siRNA stability, efficient cellular uptake, endolysosomal escape, and long-term brain availability.. The Argonaute-2 (Ago2) protein, a core component of the RNA interference machinery, naturally binds siRNA and protects it from degradation. |
![Autophagosome accumulation in GBM cells, expressed as mean fluorescence intensity (MFI), for control untreated cells and cells treated with [HuArgI (Co)-PEG5000] at 24, 48, 72, 96, and 120 hours post-treatment. Stars indicate a significant increase in autophagosome accumulation compared to untreated cells (A). Autophagosome accumulation in A172 and U251 cell lines at 72 hours post-treatment in untreated cells and cells treated with CQ, [HuArgI (Co)-PEG5000] and a combination of both. MFI is on the X-axis (FL1-H) and forward scatter is on the Y-axis (B). Immunohistochemistry staining of autophagosomes in A172 cells untreated and treated with CQ, [HuArgI (Co)-PEG5000], or a combination of both, at 24, 48, and 72 hours, post-treatment (C).](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_6220/pmc13166220/pmc13166220__ICNS_A_2666026_F0002_C.jpg)
![Western blot of Atg13 and phosphor-Atg13 on protein extracts of A172 and U251 untreated and treated with [HuArgI (Co)-PEG5000] for up to 96 hours (Atg13) (A). Histogram of the ratio of p-Atg13 over Atg13 showing a significant decrease in the phosphorylation of Atg13 at 72- and 96-hours post-treatment. Stars indicate statistical significance (A). ULK phosphorylation levels expressed as mean fluorescence intensity (MFI), for untreated cells and cells treated with [HuArgI (Co)-PEG5000] at 24, 48, 72, 96, and 120 hours post-treatment. Double stars indicate significantly lower ULK phosphorylation in treated compared to untreated cells (B). ULK phosphorylation is also shown in A172 and U251 cell lines at 24- and 48-hours post-treatment in isotype controls, untreated cells and cells treated with [HuArgI (Co)-PEG5000]. MFI is represented on the X-axis (FL1-H) and forward scatter is represented on the Y-axis. Last panel on the right is a histogram representing the overlayed phospho-ULK MFI of the isotype control (red), untreated cells (black) and cells treated with [HuArgI (Co)-PEG5000] (blue) (B). Cytotoxicity of [HuArgI (Co)-PEG5000] alone and in combination with chloroquine (CQ) (50 µM) to A172 and U251 cells at 48, 72, 96, and 120 hours (C).](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_6220/pmc13166220/pmc13166220__ICNS_A_2666026_F0003a_C.jpg)
![Intracellular ROS accumulation in GBM cells following treatment with [HuArgI (Co)|-PEG5000], expressed as both percent positive cells (left panel) and mean fluorescence intensity (MFI) (right panel). Stars indicate a significant increase in ROS accumulation. The bottom histograms show ROS accumulation in treated cells (red) compared to controls (black) in A172 and U251 cells. (A) Autophagosome accumulation in GBM cells, expressed as MFI, for control untreated cells and cells treated with [HuArgI (Co)-PEG5000] alone or a combination of [HuArgI (Co)-PEG5000] and N-acetylcysteine (NAC) at 24, 48, 72, 96, and 120 hours post-treatment (B). Autophagosome formation in A172 and U251 cell lines. Control untreated cells (left panel) and cells treated with [HuArgI (Co)-PEG5000] (10 −7 M) (middle panel) or treated with [HuArgI (Co)-PEG5000] and NAC (0.82 g/L) (right panel) at 24, 48, 72, 96, and 120-hours post-treatment. In the histogram (right panel), control cells are in black, cells treated with [HuArgI (Co)-PEG5000] are in red and cells treated with the combination with NAC are in blue (C). Cytotoxicity of A172 and U251 cells treated with [HuArgI (Co)-PEG5000] alone or in combination with N-acetylcysteine (NAC) (0.82 g/L) (D).](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_6220/pmc13166220/pmc13166220__ICNS_A_2666026_F0004a_C.jpg)